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BMC Medical Genetics

BMC Medical Genetics

We studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, Scotland, from 1992 onward. Recent national surveys show that American adults have experienced a 50% increase in the prevalence of overweight and obesity, while children and adolescents have experienced a 100% increase since the 1970s (rev. However, patients present with wide clinical heterogeneity, suggesting that modifier genes play a role in determining severity. By February 2005 with 10 years of follow up, 366 of these initially healthy women had developed incident diabetes. Relative risks in first, second, and third degree relatives and spouses of inhabitants with type 2 diabetes were compared to matched controls. Patients were interested in genetic testing for type 2 diabetes risk and believed in its importance. Their diets are based on low starch/lowcarb fresh vegetables and lowcarb fruits.

Our data indicate significant effects of H63D and C282Y on body iron stores and suggest a potential interaction between HFE genotypes and heme iron intake in relation to the risk of type 2 diabetes. The likelihood of developing type 1. In h, 50% of the variants contribute to disease risk and the remaining 50% have no effect on disease risk; in i, 100% of the variants contribute to disease risk. Diabetes is the result of a complex mix of genetic and environmental factors. Due to this complexity, elucidating the genetic causes of these multifactorial diseases has required unbiased, large-scale genome-wide approaches. In the United States, infection with hepatitis C is the more common cause of HCC, while in Asia and developing countries, hepatitis B is more common. The observation suggests that changes in transglomerular albumin traffic are demonstrable prior to the onset of diabetes and diabetic nephropathy in subjects with a potential genetic predisposition to these conditions.
BMC Medical Genetics

In a high proportion of patients with isolated growth hormone deficiency and multiple pituitary hormone deficiency, characteristic radiologic findings include (1) a small or absent anterior pituitary gland, (2) a small or truncated infundibulum, and (3) an ectopic posterior pituitary hyperintensity located at the base of the hypothalamus or inferior end of the truncated pituitary stalk. The high average glucose concentration (5.42 mmol/l) of the hypocatalasemic subjects may indicate that they have a higher (3.05×) risk of type 2 diabetes than their (4.83 mmol/l, 1.81×) normocatalasemic relatives (4). (1964). Except for the results reported by Paterson and colleagues [20] none of these gene regions have previously been shown to be associated with glycemic traits in humans or animals. Particularly interesting is that the interplay between genetics and environment also may act on this chromosomal region, e.g., the epigenetic effect of diet on the promoter regions of HNF4A [28]. (1995) reported a family with clear autosomal dominant inheritance of HMSN VIA. Our results therefore emphasize the need for further replication studies if one is to be successful in defining the true genetic risk factors involved in glycemic-related traits.

There are limitations of our study. We had access to only one HbA1c and non-fasting blood glucose value for each case, in contrast to the repeated measurements used by the DCCT investigators during the course of a carefully controlled clinical trial. Furthermore, the use of HbA1c as a quantitative trait modulated by genetic factors must be taken with caution in the context of pharmacological treatment, since treatment as an environmental variable may overwhelm the genetic signal. For each SNP, we tested for allelic association with diabetes risk under dominant, recessive, and additive models. In pedigree studies, family members outside the nuclear family are included. Our study has, however, also several important strengths. The HUNT cohort is a well-characterized, stable (net emigration around 0.3% per year) and ethnically uniform (less than 3% of the people are of non-Caucasian origin) population from a clearly defined region of Norway [31].

Our study participants were part of an all-population-inclusive survey with high attendance. Type 2 diabetes is associated with modifiable lifestyle risk factors. The HUNT samples have previously been validated by genotyping of known type 2 diabetes risk variants [23, 32] indicating that the HUNT population contains a representative diabetes cohort. But as Altshuler points out, we have little information on whether people really do make lifestyle changes in response to genetic tests. However, the locus that shows the strongest association with T2D in a number of ethnicities occurs in the wnt-signaling pathway member, transcription factor 7-like 2 (TCF7L2) [31].

السكري الكاذب Diabetes Insipidus

السكري الكاذب Diabetes Insipidus

تشير التقارير إلى أن 30% من الحالات تكون مجهولة السبب, وأن 25% منها له ارتباط بأورام الغدة النخامية, سواء الأورام الحميدة, أو الخبيثة, وأن 16% بسبب كدمات الرأس, وأن 20% تكون عقب جراحات الرأس following cranial surgery. I know, a very long word. محمد سعد عبد اللطيف السكري الكاذب Diabetes Insipidus هناك فرق بين مرض السكر الكاذب diabetes insipidus و مرض السكر diabetes mellitus رغم اشتراك المرضين في كلمة “سكر” diabetes, و أهم ما يفرق بين الحالتين هو أن البول في السكر الكاذب يكون أكثر في الكمية، وأقل في التركيز, وذلك رغم اشتراك المرضين في تسببهما في العطش وكثرة التبول. السكرِ الكاذب الناشئ مِن الكلي Nephrogenic diabetes insipidus و يسببه عدَم القدرة علي تركيز البول, بسَبب مقاومة الكلي عمل الهرمون المضاد لادرارِ البول, وهَذا النوع مِن المُمكن وجوده فِي القصورِ الكلوي المزمن chronic renal insufficiency, وتسمم الليثيوم, وزيادة مستوي الكالسيوم بالدم, وانخفاض مستوي البوتاسيوم بالدم, والامراض الَّتِي تصيب الانابيب البولية tubulointerstitial disease, كََما تُوجد حالات نادرة ناشئة عَن خلل بمستقبلات الهرمون المضاد لافراز البول بسَبب امراض وراثية بالكلى. Q.17- A 23-year-old woman has been referred from an endocrinologist for weight gain especially around the waist. If a female fetus is exposed to too much testosterone during their critical period the hypothalamus can become masculinized which would lean create masculine behaviors in the female. Also, the volume of urine output increases because the body is unable to concentrate it and it is usually very pale in color or colorless in appearance.
السكري الكاذب Diabetes Insipidus

There are cases where DI is connected with other abnormal pituitary hormones. Gestational diabetes insipidus is a rare, but well recognized, complication of pregnancy. It is also called pituitary diabetes insipidus and neurogenic diabetes insipidus and it is caused by a deficiency of a hormone celled vasopressin that has the role to increase the concentration of urine and thus decrease the urine output. و بعض الحالات قد يصاحب الأورام السرطانية مثل سرطان الرئة, والغدد الليمفية lymphoma, و سرطان كرات الدم البيضاء leukemia, و مرض اللحمانية sarcoidosis و فقدان الشهية العصبيanorexia nervosa, وعيوب الأوعية الدموية مثل التوسع الموضعي بالشرايين aneurysms. Clinical: Endocrine/Metabolic. Learn tips from for a healthy lifestyle, including diet and exercise. Vasopressin is active when the body needs to conserve water by excreting smaller amounts of urine.

يجب قياس الأملاح و المعادن بالدم serum electrolytes, و السكر glucose, و الكثافة النوعية للبول, و صوديوم البول, و الضغط الرشحي للبول urine osmolality, و الضغط الرشحي للسائل الدمويserum osmolality, و مستوى الهرمون المضاد لإدرار البول, وتؤكد نتائج التحاليل تشخيص المرض, عندما تكون الكثافة النوعية للبول 1.005, أو أقل, ويكون الضغط الرشحي للبول أقل من الضغط الرشحي العشوائي للبلازما. Nephrogenic: This form is because of a dysfunction of the kidneys in dealing with vasopressin. Diabetes can cause blood sugar too low to drop, with consequences that result from hypoglycemia.

40.000 patiënten krijgen sensor voor diabetes terugbetaald

40.000 patiënten krijgen sensor voor diabetes terugbetaald

40.000 patiënten krijgen sensor voor diabetes terugbetaald
The round device is just a bit smaller than a Double-Stuf Oreo — about 1.5 inches wide and half an inch thick — and would be implanted in a person’s torso. To achieve the goal of tight glucose control by patients with diabetes, a long-term implantable glucose sensor should meet the following functional requirements: it should be a one-time minimally invasive implantable with a wireless external unit; provide on-demand real-time glucose levels and trends; operate for up to 12 months after implantation with infrequent recalibration; contain built-in hypoglycemic and hyperglycemic alarms; and have an ergonomically designed, external, wearable user interface. We evaluated an electrochemical redundant sensor (ERS) incorporating two working electrodes (WE1 and WE2) onto a single subcutaneous insertion platform with a processing algorithm providing a single real-time continuous glucose measure. Therefore, calibration of the sensor signal must be performed by the patient himself repeatedly. As a result, “our device is more affordable, with lower running costs than existing self-monitoring systems,” he said. His hemoglobin A1c (A1C) was 9.2%, and he described losing control of his diabetes progressively through the years. Blood glucose (BG) readings from Bayer CONTOUR NEXT meters served as reference (2), with absolute relative difference (ARD) defined as the percent error between sensor and matched BG values.

Device accuracy was assessed by comparing continuous glucose values to paired self-monitoring of blood glucose (SMBG) meter readings. Severe symptoms tend to lead to disabling hypos, and these can happen often and without warning for some people with Type 1 diabetes. This means she can become unconscious (known as a diabetic coma) without warning.

MiR-133 As An Epigenetic Regulator Of Diabetic Heart Failure

MiR-133 As An Epigenetic Regulator Of Diabetic Heart Failure

MiR-133 As An Epigenetic Regulator Of Diabetic Heart Failure
Diabetic patients with ischaemic heart disease have a greater amount of myocardial ischaemia, often silent, and an increased incidence of heart failure compared to nondiabetic patients. This review outlines the key role of diabetes mellitus as a stage A risk factor for heart failure with preserved ejection fraction, and asymptomatic diabetic cardiomyopathy, referring to the presence of left ventricular diastolic dysfunction in diabetic patients without coronary artery disease, hypertension or other potential aetiologies, as an expression of stage B heart failure with preserved ejection fraction at high risk of transitioning to symptomatic stage C heart failure with preserved ejection fraction. A second aim was to characterize patients with DM with respect to severity of CHF. We related plasma copeptin to a combined end point composed of coronary artery disease (CAD), heart failure (HF), and death in diabetes (n = 895) and nondiabetes (n = 4187) individuals of the Malmö Diet and Cancer Study-Cardiovascular cohort. Dietary and exercise advice. The free radical scavenger and cardiac protectant SMe1EC2 (10 mg/kg/d.) was given orally for 5 days and 5 weeks and these animals were compared with the diabetic and non-diabetic controls. Subjects were followed from the date of incident heart failure until death, termination of insurance policy, or December 31, 2010.

GLO1 over-expression resulted in reduced inflammation: TNF-α protein expression was increased in both diabetic groups (≥2-fold), but significantly less so in GLO1-diabetic mice (p=0.03). Lead researcher Dr Rajesh Katare says the team sought to confirm their laboratory-based results by collaborating with cardiothoracic surgeons at Dunedin Hospital to collect and study heart tissue samples from coronary bypass patients. The training effect also correlated with the duration of the program.

Australia has a new food pyramid

Australia has a new food pyramid

People with diabetes can create a very healthy menu with the Mediterranean Diet Pyramid. Traditionally the food pyramid has been used as an educational tool to aid in the understanding of the relative importance of different foods in achieving dietary balance. The Mediterranean diet was associated with a decreased incidence of metabolic syndrome and its components. In this group you also have dried beans like black eyed peas and red kidney beans, The reason these food are in this group is because they contain about the same amount of carbs per serving. What struck me as odd was that almost every picture was of a carbohydrate – fruits, pasta, muffins, salads, tacos shells, whole grain bread, tortillas, and cereals. They believe a Low-Carb, High-Fat (LCHF) diet can fight obesity and diabetes all at once. Diabetes is a chronic condition that affects over 150 million people in the world today.

Australia has a new food pyramid
The added fourth level includes legumes, nuts, seeds, and oils for healthy fats. The next group is milk, meat, meat substitutes and other proteins. Saturated Fatty Acids are usually solid at room temperature and are found mainly in foods from animal sources like meat, and dairy products, like butter and cheese. We’ve found that one of the most interesting aspects of Dr Swilling’s work is that he takes a “holistic” or ‘all-round” view of the body and its reactions to disease. The American people haven’t been so lucky. Legumes (inc. As an African-American and a registered dietitian, I’m pretty excited about this new pyramid.

Weight training is a fantastic way to stay in shape and get fitter because it is low impact. Personally, I would have put legumes such as chickpeas and lentils in the grains category, simply because unlike vegetables they have a significant carbohydrate load. Reduce your consumption of foods made with wheat flour and sugar, especially bread and most packaged snack foods (including chips and pretzels). Because of the health risks associated with overconsumption of saturated fat, cholesterol, and sodium, high levels of these nutrients are reported as “Bad,” while high levels of more essential nutrients are reported as “Good.” Nutrition Data also reports if more than 20% of the calories in the food come from sugars or alcohol, and if the food contains any trans fat. You could serve it with barley, quinoa or even brown rice which has a moderate glycemic index. When foods are groups according to type, there are inconsistencies, as seen with vegetables, fruits and legumes in which they can cross categories based on their carbohydrate and calorie contents. The website goes into more detail on how to make wise choices in this category, basically choosing lean meats and lower saturated-fat options.

So in short, multigrain rice may be of low glycaemic value, but if you eat a large portion of it, it can your blood glucose levels shoot up. Even common supplements, such as caffeine have their limits (no more than 600 milligrams per day). Good nutrition is not complicated, it is actually very easy and the take-home message for all of us is just eat more vegetables and you will be on the right track.

Charity’s diabetes prescription fine victory

Charity's diabetes prescription fine victory

Patients will answer seven questions on risk factors including age, gender, waist circumference and ethnic background and will be referred to their GP if the pharmacist considers them to be at risk. Physical inactivity and a sedentary lifestyle are both associated with 21st century living. About 15% of all couples experience infertility, and about half the time, this is due to male infertility. Brooklyn Gigolyk has crammed a lot into her 18 years. A nice change of pace. Funds are divided between The Fund for Animals and Humane Society of the United States (HSUS), the International Fund for Animal Welfare (IFAW), and Rescue Bank. Some foot ulcers become deep, extending down into the tendons and bones within the foot.
Charity's diabetes prescription fine victory

Commenting in an emailed statement, Dr Emily Burns, Diabetes UK research communications manager, says: “A number of studies have highlighted an interesting connection between sleep difficulties and an increased risk of type 2 diabetes, but further research is still needed to understand why. Last month the Government agreed to give people the chance to get a medical exemption certificate before requiring them to pay a penalty charge. The first layer is gauze that has been soaked in medicines and lotions to help your wound heal. Diabetes UK says this new commitment confirms that those who were fined before these changes were announced will be treated equally with those whose penalty charge notice was issued under the new system. One might think I’m employed by National Diagnostic Products, the manufacturer. If you have diabetes, you should check your feet daily for damage, after washing and drying them. With podiatrist-trusted, orthopedic footwear from Mephisto, MBT, Vionic with Orthaheel Technology and Dansko, you’ll no longer have to search high and low online for attractive, healthy shoes.

METHODS Ten normal subjects, without any prior foot or ankle problems, were recruited for this study.

10 Foods that Increase Sperm Count

10 Foods that Increase Sperm Count

Men wanting to become fathers should “put down that English breakfast” the Daily Mail has today declared, as research has linked a diet high in saturated fat to a reduced sperm count. It effectively helps in erectile dysfunction, premature ejaculation, low sperm count and low sperm motility. A great number of medical conditions as well as many biologic and environmental factors can cause low sperm count temporarily or permanently. Having a low sperm count decreases the odds that one of your sperm will fertilize your partner’s egg, resulting in pregnancy. Your sperm count is considered lower than normal if you have fewer than 15 million sperm per milliliter of semen. A phase II clinical trial is the second of four phases used to test a drug for safety and effectiveness before it is submitted to the Food and Drug Administration for approval. This condition can be a side-effect of bladder neck surgery, diabetes mellitus or alpha-adrenergic drugs.

These will include steps to prevent diabetes and diagnose, treat and care for people with diabetes. Below are some of the best health benefits of Himalaya spemen. That is why it is very essential to refresh and restore the zinc supply with foods high in zinc like oysters and other shellfish. Thus, MTEC (modified) has promising hyperglycemic, antioxidative, and antiapoptotic activities for curing diabetes-induced testicular disorders in a streptozotocin-treated diabetic rat model. The fact that you have tried for at least four years and you have not become pregnant is significant. Nima Thakkar Jagruti A Patel. As the fetus develops, the XY gene promotes the development of the testis.

The whitish fluid that shows when plantain leaf is cut is very effective for treating wounds, especially fresh wounds. I am a 32-year-old male, and I have diabetes and use insulin. Sexual issues: If you are facing sexual issues like intercourse problems or technique or differences with your partner about the way you have intercourse, you may suffer from a lower sperm count. Alcohol can lower the production of sperm and of the male hormone testosterone. In contrast, in a latex condom, the quality decreases by 60-80%[23] per hour, rendering the sample unusable in a relatively short time. There’s another reason to get help, Lipschultz says. The roots of this herb pacify vata and balance doshas.
10 Foods that Increase Sperm Count

Second, stabilizes blood sugars throughout the day. 3. Why doctors fail to diagnose hypothyroidism? In a small 2013 HSPH study of 189 men ages 18 to 22, participants were asked about their TV watching and exercise habits. Let us know on social media or in the comments below. Beef is a rich source of zinc which possesses protective properties that prevent free radicals from becoming part of sperm. Zinc stops testosterone from converting into estrogen which is responsible for low libido.

Three months after she transformed her diet from processed to whole, fresh, real foods, started exercising daily and began taking nutritional supplements that support normal blood sugar metabolism, Lisa got pregnant naturally. As mentioned earlier, walnuts contain arginine that helps in the increased production of sperm and also boosts semen volume. Bhasin S, Cunningham GR, Hayes FJ, et al. Lump – Another red flag that tells you are suffering from low sperm count is when you notice a lump or swelling in the testicle area. An amazing fact about walnuts is that having 7 walnuts a day lowers cholesterol and the risk of heart attack. Making a Baby: Everything you need to know to get pregnant. These tubes cannot be replaced.

Vegetables enriched in folic acid help contribute to sperm count. Both the sperm count and percentage of morphologically normal sperm cells were significantly reduced (P < 0.05) compared with the control animals. Fruits like oranges, strawberries, cherries, and other antioxidant-rich fruits are effective in boosting sperm count and preventing damage to sperm. Side effects: This treatment is harmless because we give well proven drugs which are prescribed in scientific literature. By making eating fruits a habit, it can help counteract free radical damage. Male fertility tests: The initial test can be carried out by most doctors and involve a physical examination of the testes area. Supplementation with cobalamin may reverse the deficiency, however, the ideal dose when given orally is yet to be determined. He is an ardent student of classical Homeopathy. Eggs are rich in vitamin E, a deficiency of which is responsible for testicular tissue degeneration. The antioxidant quality of vitamin E helps counteract the negative effects of free radicals on sperm and egg and therefore this vitamin is considered one of the most important nutrients for fertility. When the embryos are big enough, they can be implanted. It’s necessary to keep your body hydrated in order to boost the functioning of cells, including sperm. Drinking 8 to 10 glasses of water a day can help your sperm to go a long way.

Depression and Insomnia

Depression and Insomnia

In Phase III controlled clinical studies involving 613 patients treated with MEVACOR, the adverse experience profile was similar to that shown below for the 8,245-patient EXCEL study (see Expanded Clinical Evaluation of Lovastatin [EXCEL] Study). Sometimes chronic insomnia can be a red flag for conditions that require medical referral (e.g., depression). Sleep is important for everyone, but it’s especially important when your body experiences changing blood sugar levels and other symptoms of type 2 diabetes. Such individuals usually suffer fatigue, difficulty concentration, irritability, day time sleepiness, and headaches. It’s treasured for its healing properties, but it can be hard to separate the myths from the facts. Glucose rises after a meal, and insulin grabs the sugar and transports it to the cells where it is used for fuel. CBT has none of the risks of drugs and uses methods such as relaxation techniques, sleep restriction, stimulus control, and education to produce better sleep.
Depression and Insomnia

He still suffered from sleep apnea, so he resumed use of the CPAP machine and now dozes more comfortably than he has in years. To have relief from loose motion issues just mix about a glass of yogurt with five grams of cumin that has been roasted and grinded. This is because it disrupts the normal sleep cycle. When the body doesn’t receive adequate rest, it begins to release more of the stress hormone cortisol, which can break down skin collagen. This medicine is used in heart failure, where the pumping mechanism of the heart is less effective. The findings suggest that circadian disruptions combined with inadequate sleep affect the body differently than does sleep deprivation alone. In one study, 56 people who suffered both depression and insomnia received psychotherapy for their sleep problems alone.

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Neither Averting Nor Craving in Each Moment : zen habits

Neither Averting Nor Craving in Each Moment : zen habits

Omega-3 supplementation reduces nicotine cravings, helping smokers quit 12/20/2014 – In the largest city of northern Israel, the University of Haifa has shared their concluded research showing that omega-3 supplementation significantly reduces nicotine craving, not to mention the number of cigarettes a person smokes on any given day. The food cravings is usually related to sugary foods, but may include non-sugary foods such as cravings for food containing certain nutrients necessary in serotonin production. High blood sugar can be caused by a number of factors including frequent snacking on processed foods and drinks, sugar cravings or hunger pangs between meals, over-eating refined foods, regular dieting and weight gain. Now here’s where things get even more interesting. Breastmilk is naturally sweet and has important carbohydrates that not only feed the baby, but feed the baby’s gut bacteria as well. Eating foods that are high in sugar and fat causes our insulin levels to spike. The best way to confirm that fact is to watch kids eating.
Neither Averting Nor Craving in Each Moment : zen habits

I eat other breads at home and don’t have this happen, so it must be a powerful bread at that restaurant. Nature has many sweet treats that can fully satisfy your cravings. Or, we may suffer from the feelings of high blood sugars including lethargy, blurry vision, increased urination, and grumpiness. Supplements of magnesium  can reduce sugar craving and help stabilise blood sugar levels[1]. Not what you read into the moment, but what’s really there, in terms of light and sound and physical molecules. It isn’t new I mean, but hopefully you understand what I’m trying to say~? Just accept it.

Some people who have diabetes don’t get Alzheimer’s and some people with Alzheimer’s disease don’t have diabetes. You don’t have to deal with cravings at all.

Government strategies for diabetes and childhood obesity encouraging

Government strategies for diabetes and childhood obesity encouraging

Government strategies for diabetes and childhood obesity encouraging
26 May 2016 – The report of the Commission on Ending Childhood Obesity formed the basis for a side event, hosted by Ghana, Malaysia and Mexico, along with New Zealand and Zambia during the Sixty-ninth World Health Assembly. (1) reflects the fact that maternal nutrition plays an important role in the pathogenesis of childhood obesity. She plans to continue on with her education, complete a master’s degree program in nutrition and, ultimately, become a registered dietitian. It has been suggested that prenatal, perinatal and postnatal environmental factors impact childhood obesity. Growth charts are provided by the Centers for Disease Control and Prevention and can be found here. formula only). The long-held conventional view that obesity is either the result of “bad genetics” or poor lifestyle choices, combined with a certain amount of laziness or lack of willpower, has now largely been debunked.

For toddlers and preschoolers aged 2-5, the obesity levels have risen from 5% to 12.4% in the same amount of time. The following offers an overview of current trends and initiatives from both sectors and concludes with some thoughts on what the future may hold. And the food industry had powerful friends: In 2003 the Bush administration threatened to eliminate all U.S.